Inherited Predisposition

The field cancerization theory suggests that multiple genetic abnormalities occur throughout the respiratory epithelium as a result of longterm carcinogen exposure.
 Mutations may occur during adult life as a result of cigarette smoking, but it is also possible that some of them may be acquired during embryonic development of the bronchial epithelium.
 Inherited Predisposition to Lung Cancer A predisposition to early age of onset of lung cancer may be inherited in a Mendelian amoxicillin codominant fashion.
 COPD is associated with the development of lung cancer, and there appears to be a familial correlation with the development of such respiratory disease.
 Inheritance of an abnormality in carcinogen metabolism is another possibility.
 Inheriting genes predisposing to malignancy usually results in a high rate of secondary tumors (lung, head and neck, esophagus, and other organs).
 For example, patients cured of laryngeal tumors vantin have an increased risk of lung cancer.
 Lung Cancer in Never Smokers A small proportion of patients with lung cancer do not have a significant history of cigarette use (defined as 100 cigarettes in a lifetime).
 In the United States, 10 to 15% of lung cancer candida occurs in never smokers (5 to 10% in men and 15 to 25% in women).
 This rate is greater than that of ovarian cancer or Hodgkin disease.
 Worldwide, 15% of men and 53% of women with lung cancer are neversmokers.
 The cause of lung cancer in neversmokers is uncertain.